Gene information
Official symbol MMP13
Official full name matrix metallopeptidase 13
Gene type protein-coding gene
Chromosome11q22.2
Alias symbolCLG3
Gene familyReceptor ligands; M10 matrix metallopeptidases
Resources
Entrez Gene 4322
HGNC HGNC:7159
Ensembl ENSG00000137745
Vega OTTHUMG00000165850
UCSC uc001phl.4
GO terms: 40 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001958 endochondral ossification GO Biological Processes -3.90690001 7 More
GO:0003416 endochondral bone growth GO Biological Processes -3.39931914 4 More
GO:0003417 growth plate cartilage development GO Biological Processes -4.11747892 4 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004222 metalloendopeptidase activity GO Molecular Functions -10.6700212 15 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005518 collagen binding GO Molecular Functions -7.71267127 10 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008237 metallopeptidase activity GO Molecular Functions -10.3008607 18 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022617 extracellular matrix disassembly GO Biological Processes -9.45487411 10 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030282 bone mineralization GO Biological Processes -8.89624301 10 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030574 collagen catabolic process GO Biological Processes -13.3732998 12 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031214 biomineral tissue development GO Biological Processes -8.35916144 12 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0035265 organ growth GO Biological Processes -9.67739919 20 More
GO:0036075 replacement ossification GO Biological Processes -3.90690001 7 More
GO:0040007 growth GO Biological Processes -14.0580178 53 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0048589 developmental growth GO Biological Processes -14.0580178 53 More
GO:0048705 skeletal system morphogenesis GO Biological Processes -7.04838258 29 More
GO:0051216 cartilage development GO Biological Processes -10.5011549 17 More
GO:0060348 bone development GO Biological Processes -12.2474877 36 More
GO:0060349 bone morphogenesis GO Biological Processes -6.25068095 17 More
GO:0060350 endochondral bone morphogenesis GO Biological Processes -6.37680507 13 More
GO:0060351 cartilage development involved in endochondral bone morphogenesis GO Biological Processes -4.39105986 5 More
GO:0061448 connective tissue development GO Biological Processes -12.1108226 21 More
GO:0098868 bone growth GO Biological Processes -4.61361828 8 More
GO:0110148 biomineralization GO Biological Processes -9.16361193 13 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1904645 response to amyloid-beta GO Biological Processes -11.2505232 12 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04926 Relaxin signaling pathway KEGG Pathway -10.8215200 16 More
hsa04928 Parathyroid hormone synthesis, secretion and action KEGG Pathway -3.30201840 7 More
Drug-Gene interaction
view
Related drugs: 6 records
Drug name Interaction type Source PMID View
apratastat inhibitor TTD view
curcumin TTD view
doxycycline inhibitor ChemblInteractions view
doxycycline calcium inhibitor ChemblInteractions view
doxycycline hyclate inhibitor ChemblInteractions view
prinomastat inhibitorvaccine TALC view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
collagenase 3 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Suzuki H et al. Eur J Clin Invest. 2008
NM_002427.4:c.799+92A>G genomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Pavkova Goldbergova M et al. J Appl Genet. 2017
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